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Leaked report shows Pfizer’s vaccine is sharply cutting covid-19 infections in Israel

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Leaked report shows Pfizer's vaccine is sharply cutting covid-19 infections in Israel


Pfizer did not confirm the authenticity of the study document. Its lead authors are Sharon Alroy-Preis, head of public health for Israel’s health ministry, and Eric Haas, a ministry researcher. In addition, the study was carried out by a team of eight Pfizer researchers, including epidemiologists Farid Khan and John McLaughlin and the company’s global medical lead for covid vaccines, David Swerdlow, an infectious disease expert previously with the US Centers for Disease Control and Prevention.

The research represents the first joint report by the health ministry and Pfizer since they reached an agreement earlier this year for Israel to share vaccination data in return for a steady supply of doses.

The cooperation is part of a wider effort by Pfizer to track how its vaccine, named Comirnaty, works in large populations. The company told MIT Technology Review earlier this week that it is studying “the vaccine’s real-world effectiveness at several locations worldwide, including Israel,” and “particularly looking at real-world data from Israel to understand any potential impact of the vaccine to protect against covid-19 arising from emerging variants.” Pfizer’s vaccine, like one from Moderna, another mRNA vaccine authorized for use in the US and Europe, uses two injections of messenger RNA carrying information about the virus to train people’s immune system to recognize and combat the infection.

The new findings are broadly consistent with separate announcements in recent days from two of Israel’s large health organizations, Maccabi Healthcare Services and Clalit Health Services, which together care for 80% of Israelis.

On February 14, Ran Balicer, chief of innovation and research at Clalit, the largest Israeli HMO, said that evidence collected on 1.2 million members “shows unequivocally that Pfizer’s coronavirus vaccine is extremely effective in the real world a week after the second dose.”

Other analyses suggest that serious infections and deaths have fallen among older Israelis, who got the vaccine first, but not among those younger than 44 who have not been vaccinated.   

The Israeli report describes observations made during three weeks in January and February when researchers were able to compare health records of unvaccinated people and people who had gotten their second shot more than a week before. They then compared the groups for five covid-19 outcomes: infection, symptoms, hospitalizations, critical hospitalization, and death. The unpublished study says the vaccine was around 93% effective in preventing symptomatic covid-19. Pfizer and its partner, the German biotechnology firm BioNTech, had found 95% effectiveness in their clinical trials carried out in 2020. The country-wide study was also able to show that hospitalizations and deaths dropped by similar amounts in the vaccinated group.

Because Israel tests people fairly comprehensively, the researchers were also able to estimate that the vaccine was 89.4% effective in preventing any detectable infection at all, including asymptomatic infections.

That finding, which is new, suggests that the vaccine could strongly suppress transmission of the virus between people and could help bring the outbreak to an end, a possibility Pfizer and the Israeli researchers say they are closely watching. “Israel provides a unique opportunity to observe the nation-wide impact of an increasing prevalence of immunity on Sars-Cov-2 transmission,” the authors wrote. Eric Topol, a doctor at Scripps Research in California, who reviewed the document, says that “the blocking of infections here speaks to the vaccine’s impact on asymptomatic transmission, which we’ve been unsure about.”

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How to poison the data that Big Tech uses to surveil you

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How to poison the data that Big Tech uses to surveil you


In a new paper being presented at the Association for Computing Machinery’s Fairness, Accountability, and Transparency conference next week, researchers including PhD students Nicholas Vincent and Hanlin Li propose three ways the public can exploit this to their advantage:

  • Data strikes, inspired by the idea of labor strikes, which involve withholding or deleting your data so a tech firm cannot use it—leaving a platform or installing privacy tools, for instance.
  • Data poisoning, which involves contributing meaningless or harmful data. AdNauseam, for example, is a browser extension that clicks on every single ad served to you, thus confusing Google’s ad-targeting algorithms.
  • Conscious data contribution, which involves giving meaningful data to the competitor of a platform you want to protest, such as by uploading your Facebook photos to Tumblr instead.

People already use many of these tactics to protect their own privacy. If you’ve ever used an ad blocker or another browser extension that modifies your search results to exclude certain websites, you’ve engaged in data striking and reclaimed some agency over the use of your data. But as Hill found, sporadic individual actions like these don’t do much to get tech giants to change their behaviors.

What if millions of people were to coordinate to poison a tech giant’s data well, though? That might just give them some leverage to assert their demands.

There may have already been a few examples of this. In January, millions of users deleted their WhatsApp accounts and moved to competitors like Signal and Telegram after Facebook announced that it would begin sharing WhatsApp data with the rest of the company. The exodus caused Facebook to delay its policy changes.

Just this week, Google also announced that it would stop tracking individuals across the web and targeting ads at them. While it’s unclear whether this is a real change or just a rebranding, says Vincent, it’s possible that the increased use of tools like AdNauseam contributed to that decision by degrading the effectiveness of the company’s algorithms. (Of course, it’s ultimately hard to tell. “The only person who really knows how effectively a data leverage movement impacted a system is the tech company,” he says.)

Vincent and Li think these campaigns can complement strategies such as policy advocacy and worker organizing in the movement to resist Big Tech.

“It’s exciting to see this kind of work,” says Ali Alkhatib, a research fellow at the University of San Francisco’s Center for Applied Data Ethics, who was not involved in the research. “It was really interesting to see them thinking about the collective or holistic view: we can mess with the well and make demands with that threat, because it is our data and it all goes into this well together.”

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Four new hacking groups have joined an ongoing offensive against Microsoft’s email servers

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Four new hacking groups have joined an ongoing offensive against Microsoft’s email servers


A Chinese government-linked hacking campaign revealed by Microsoft this week has ramped up rapidly. At least four other distinct hacking groups are now attacking critical flaws in Microsoft’s email software in a cyber campaign the US government describes as “widespread domestic and international exploitation” with the potential to impact hundreds of thousands of victims worldwide.

Beginning in January 2021, Chinese hackers known as Hafnium began exploiting vulnerabilities in Microsoft Exchange servers. But since the company publicly revealed the campaign on Tuesday, four more groups have joined in and the original Chinese hackers have dropped the pretense of stealth and increased the number of attacks they’re carrying out. The growing list of victims includes tens of thousands of US businesses and government offices targeted by the new groups. 

“There are at least five different clusters of activity that appear to be exploiting the vulnerabilities,” says Katie Nickels, who leads an intelligence team at the cybersecurity firm Red Canary that is investigating the hacks. When tracking cyberthreats, intelligence analysts group clusters of hacking activity by the specific techniques, tactics, procedures, machines, people, and other characteristics they observe. It’s a way to track the hacking threats they face. 

Hafnium is a sophisticated Chinese hacking group that has long run cyberespionage campaigns against the United States, according to Microsoft. They are an apex predator—exactly the sort that is always followed closely by opportunistic and smart scavengers.

Activity quickly kicked into higher gear once Microsoft made their  announcement on Tuesday. But exactly who these hacking groups are, what they want, and how they’re accessing these servers remain unclear. It’s possible that the original Hafnium group sold or shared their exploit code or that other hackers reverse engineered the exploits based on the fixes that Microsoft released, Nickels explains.

“The challenge is that this is all so murky and there is so much overlap,” Nickels explains. “What we’ve seen is that from when Microsoft published about Hafnium, it’s expanded beyond just Hafnium. We’ve seen activity that looks different from tactics, techniques, and procedures from what they reported on.” 

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As the Texas power crisis shows, our infrastructure is vulnerable to extreme weather

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As the Texas power crisis shows, our infrastructure is vulnerable to extreme weather


On Valentine’s Day, a rare burst of Arctic air spread across the central US and into Texas, dropping temperatures there into the single digits and nearly causing the state’s power grid to collapse. A state known for its abundant energy resources saw widespread failures of natural-gas and electricity systems that left more than four million Texans without power for days.

The proximate cause of Texas’s grid failure is now well understood. Frigid temperatures drove electricity demand to a new winter record that exceeded even the “extreme” demand scenario considered by the state’s power grid operator, the Electric Reliability Council of Texas, or ERCOT. Then dozens of natural-gas power plants and some wind turbines rapidly went offline, plunging the Texas grid into crisis. To prevent the whole grid from going down, ERCOT ordered utilities to initiate emergency blackouts and disconnect millions of customers. 

Scientists are still working to determine whether the fast-warming Arctic is driving more frequent breakdowns of the “polar vortex,” which precipitated the Texas freeze. But we know that climate change is making extreme weather like heat waves, droughts, wildfires, and flooding more frequent and more severe. Any of these events can push our critical infrastructure to the breaking point, as happened in Texas. How can we prepare?

Climate resilience will require investment of up to $100 billion per year globally in our infrastructure and communities. But careful planning can help our scarce resources go further. 

Looking back, Texas’s troubles offer several key lessons for how to make both critical infrastructure and vulnerable communities everywhere more resilient to climate extremes. 

Assessing future risks

First, it’s worth noting that grid failure alone did not lead to the intense suffering and loss of life Texas residents faced.

Natural-gas wells and gathering lines also froze, cutting gas production and supply for the state’s pipelines and power plants in half just as demand soared. Elsewhere, water treatment plants lost power, and frozen pipes caused water distribution networks to lose pressure. Frozen roadways prevented residents from traveling safely.

Building resilient infrastructure means paying close attention to extreme events that can slam large parts of the system all at once.

The connections between these infrastructure systems keep the lights on and taps flowing in good times but can compound failure when things go bad.

Extreme weather also tends to cause multiple parts of critical systems to fail at the same time. These kinds of simultaneous failures are far more probable than one might think. If 10 power plants each have a 10% chance of failure but these probabilities are all independent, the chance that they all fail simultaneously is infinitesimal (0.00000001%).

A 1% chance that 10 power plants all fail at once is far more worrisome. So building resilient infrastructure means paying close attention to extreme events that can slam large parts of the system all at once, whether that’s a winter storm, wildfire, hurricane, or flood.

Lastly, the worst human impacts of any infrastructure failure don’t come from the outage itself. They come from exposure to freezing temperatures, a lack of clean water to drink, dwindling food supplies, and the fear that help may not come soon enough. So the magnitude of suffering is determined not only by the magnitude of the infrastructure failure but also by each community’s ability to weather the storm.

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